<p>(A, B) Triple staining for TUNEL in red, insulin in green and 4′,6-diamidino-2-phenylindole (DAPI) in blue was performed on fixed, paraffin-embedded sections from isolated islets from 9-week old mice treated for 2 h with or without 50 µM H<sub>2</sub>O<sub>2</sub>. (B) Results are expressed as percentage of TUNEL-positive β-cells±SE. The mean number of β-cells counted was 700 for each treatment condition. (C) Glucose tolerance test with 2 mg/g BW glucose: Fasting and glucose stimulated plasma glucose levels are significantly lower in 12–16 week old <i>Hq</i> mutant mice (n = 9) compared to age-matched WT mice. Data are shown as mean + SE. *p<0.05 in <i>Hq</i> mutant mice vs. wt mice. **<i>p</i><0.05 in H<sub>2</sub>O<sub>2</sub> treated ...
(A) Representative immunofluorescent images of islets by cleaved caspase-3 (red), β-cell marker insu...
<p>During IP-GTT (6 hr fasting, 1.5 mg glucose/g body weight), <i>Dp(11)17/+</i> mice demonstrate (A...
<p>NOD mice were diagnosed with recent-onset diabetes after two consecutive days with measurements o...
<p>(A). Representative Western blots (panel 1,3) and PCR analyzes (panel 2,4) of AIF expression in i...
<p>(A) Blood glucose (mM) levels after 23 weeks feeding before and after gavage of glucose (2 g/kg) ...
<p>A Representative islets showing insulin (red) and Ki67 (green, indicated by arrows), insulin (red...
<p>(A) Isolated human pancreatic islets were exposed to siRNA to AIF (siAIF) or scrambled control si...
<p><i>A</i>. Nuclear PCNA (green) and insulin (red) staining show same level of proliferating beta c...
) mutant mice, which are hypomorphic for AIF. mutant mice are arrested in the G2 phase and are unlik...
<p>A) Fasted glucose of WT (n = 6) and T1R3 KO (n = 9) mice. B) IP GTT in WT (n = 6) and T1R3 KO (n ...
BACKGROUND:Apoptosis is a hallmark of beta-cell death in both type 1 and type 2 diabetes mellitus. U...
<p>Glucose levels during a glucose tolerance test in LF (<b>A</b>)- and HF (<b>C</b>) diet-fed Het G...
<p>(<b>A</b>) Blood glucose levels in WT, <i>Mbd5<sup>+/−</sup></i> and <i>Mbd5<sup>−/−</sup></i> mi...
<p>(A) Blood glucose levels (mg/dl) in fasted and ad-lib fed TG mice and their control littermates a...
The NOD/Lt mouse, a widely used model of human autoimmune IDDM, was used to establish the mode of β-...
(A) Representative immunofluorescent images of islets by cleaved caspase-3 (red), β-cell marker insu...
<p>During IP-GTT (6 hr fasting, 1.5 mg glucose/g body weight), <i>Dp(11)17/+</i> mice demonstrate (A...
<p>NOD mice were diagnosed with recent-onset diabetes after two consecutive days with measurements o...
<p>(A). Representative Western blots (panel 1,3) and PCR analyzes (panel 2,4) of AIF expression in i...
<p>(A) Blood glucose (mM) levels after 23 weeks feeding before and after gavage of glucose (2 g/kg) ...
<p>A Representative islets showing insulin (red) and Ki67 (green, indicated by arrows), insulin (red...
<p>(A) Isolated human pancreatic islets were exposed to siRNA to AIF (siAIF) or scrambled control si...
<p><i>A</i>. Nuclear PCNA (green) and insulin (red) staining show same level of proliferating beta c...
) mutant mice, which are hypomorphic for AIF. mutant mice are arrested in the G2 phase and are unlik...
<p>A) Fasted glucose of WT (n = 6) and T1R3 KO (n = 9) mice. B) IP GTT in WT (n = 6) and T1R3 KO (n ...
BACKGROUND:Apoptosis is a hallmark of beta-cell death in both type 1 and type 2 diabetes mellitus. U...
<p>Glucose levels during a glucose tolerance test in LF (<b>A</b>)- and HF (<b>C</b>) diet-fed Het G...
<p>(<b>A</b>) Blood glucose levels in WT, <i>Mbd5<sup>+/−</sup></i> and <i>Mbd5<sup>−/−</sup></i> mi...
<p>(A) Blood glucose levels (mg/dl) in fasted and ad-lib fed TG mice and their control littermates a...
The NOD/Lt mouse, a widely used model of human autoimmune IDDM, was used to establish the mode of β-...
(A) Representative immunofluorescent images of islets by cleaved caspase-3 (red), β-cell marker insu...
<p>During IP-GTT (6 hr fasting, 1.5 mg glucose/g body weight), <i>Dp(11)17/+</i> mice demonstrate (A...
<p>NOD mice were diagnosed with recent-onset diabetes after two consecutive days with measurements o...