Magnitude of CD4+ and CD8+ T Cell Responses to HIV-1 Gag and CMV pp65. at each of the three study visits.

<p>Proportion of IFN-γ+ and IFN-γ+IL-2+ CD8+ (columns 1 and 2) and CD4+ (columns 3 and 4) T cells, responding to stimulation with Gag and pp65 peptide pools. Results for visit 1, prior to antiretroviral therapy visit 2, during a virologically suppressive anti-retroviral regimen, and visit 3, after patients had halted an anti-retroviral regimen and viremia had rebounded are shown in upper, middle and lower rows respectively. Black bars indicate differences between HIV-1 Gag and CMV pp65 responses by response category (Wilcoxon 2 Sample Test). Red dot (1^st column, 2^nd row) notes a significant change from baseline (visit 1) values (Sign Rank Test). Only the CD8+ T cell IFN-γ response to Gag was observed to significantly change (in this case decline) from visit 1 to either visit 2 or visit 3.