Strain performance at baseline in the 5C-CPT.

<p>Performances of C57BL/6J and DBA/2J mice were compared at baseline in the 5-choice continuous performance test (5C-CPT). The 5C-CPT was adapted from the 5CSR task and includes no-go trials, requiring greater stimulus and inhibitory control. The two strains of mice demonstrated equal ability in discriminating between target locations as measured by accuracy (A). A trend towards greater %Omissions in DBA/2J mice was observed however (B). No significant strain effects on mean correct latency (C) or premature responses (D) were observed. The inclusion of no-go trials in the 5C-CPT allowed the use of signal detection theory, with which the sensitivity index (SI) could be calculated as an index of vigilance performance, consistent with human CPTs. Differences in SI were observed between the two strains (E), although this was not significant. SDT was also used to calculate responses index (RI) bias (F). There were trends toward poorer SI levels and more conservative responding in DBA/2J mice. Data presented as mean+s.e.m., and <i>$</i> denotes <i>p</i><0.1 when compared to C57BL/6J mice.