BMP-7 does not inhibit subcutaneous bleomycin-induced skin and lung fibrosis.

<p>Total collagen in the (A) skin or (B) lungs of mice challenged daily with subcutaneous bleomycin and treated daily with either BMP-7 (hatched bars) or vehicle control (filled bars) (mean±S.E.M. of n = 8 mice/group). JE/CCL2 protein levels were measured by luminex in (C) skin and (D) lung homogenates of subcutaneous bleomycin-challenged mice. Each data point represents one animal, with bars representing the mean. For differences in Bleomycin challenged in comparison to naïve control groups * indicates p<0.05, **p<0.01, ***p<0.005 statistical significance.