Aβ42 induced rough eye phenotype is sensitive to <i>Toll</i> activity.

<p>WT: Wild type flies. Aβ: pGMR-Aβ42 transgenic flies. In the experiments shown in this figure, the flies are hemizygous for the pGMR-Aβ42 transgene. Panel A: WT: eye of a wild type fly. Aβ/+: eye of a wild type fly hemizygous for the pGMR-Aβ42 transgene. Panels B through F show sibling pGMR-Aβ42 transgene flies that are either wild type <i>Tl</i> or heterozygous for the indicated <i>Tl</i> allele. Panel B: Aβ/+: hemizygous for the Aβ transgene; Aβ/<i>Tl^r4</i>: heterozygous for the LOF allele <i>Tl^r4</i>. Panel C: Aβ/+: hemizygous for the Aβ transgene; Aβ/<i>Tl^r3</i>: heterozygous for the LOF allele <i>Tl^r4</i>. Panel D: Aβ/+: hemizygous for the Aβ transgene; Aβ/<i>Tl^KG</i>: heterozygous for the LOF allele <i>Tl^KG03609</i>. Panel E: Aβ/+: hemizygous for the Aβ transgene; Aβ/<i>Tl^rk</i>: heterozygous for the LOF allele <i>Tl^rK343</i>. Panel F: Aβ/+: hemizygous for the Aβ transgene; Aβ/<i>Tl³</i>: heterozygous for the GOF allele <i>Tl^r3</i>.