Quantification of the RGC axon terminal projections to all visual structures in control and glaucomatous animals.

<p>Structures analyzed in control animals (n = 8, black) and operated animals (n = 6, white) include the suprachiasmatic nucleus (SCN), dorsal lateral geniculate nucleus (dLGN), ventral lateral geniculate nucleus (vLGN), intergeniculate leaflet (IGL), pretectum (PRT) and superior colliculus (SC). For each structure, the ipsi and contralateral densities are summed and represent the integral optical density (IOD) for all the sections obtained from the entire structure. The scale on the right corresponds to values for the total summed density of RGC projections for all structures). The difference in IOD was significant for all structures and for the total amount of projections. (Mann Whitney; * p<0.05). B shows the percent reduction of the IOD value of retinal fiber projections in visual structures of laser-operated eyes compared to the mean IOD value of the projections from unoperated control eyes. Percent reductions range from ∼50–70% depending on the structure. Errors bars in A and B are S.E.M.