Effect of delayed treatment with equitoxic doses of T-705 and ribavirin on PICV infection in hamsters.

<p>Drugs were given orally twice per day for 7 days starting on day 5, 6 or 7 for the drug-treated groups and day 7 for the placebo group. T-705 was dosed at 160 mg/kg/day on the first day and 80 mg/kg/day thereafter. Ribavirin was given at 22 mg/kg/day on the first day and 11 mg/kg/day thereafter. Hamsters were observed 28 days for (A) survival and weights and standard deviations of survivors are shown for treatments initiated on day (B) 5, (C) 6 or (D) 7. The 0.4% CMC-treated placebo and sham-infected, untreated groups are included in B–D for comparison. For the survival analysis, *P<0.05; ***P<0.001 compared to placebo-treated hamsters by log-rank test. ^a P<0.05 compared to hamsters receiving ribavirin treatment starting on the same day.