CD8+ T cell maturation patterns lymphocytes in ASCT recipients (ASCT), in HIV-infected patients (HIV) and healthy controls (HC).

<p>The percentage of <i>naïve</i> CD8+ T cells (CD45RA+CCR7+) (A), <i>central memory</i> (CD45RA−CCR7+) (B), <i>effector memory</i> (CD45RA−CCR7−) (C) and <i>effector</i> cells (CD45RA+CCR7−) (D) were compared in the groups. Higher levels of <i>naïve</i> CD8+ T-cells were observed in ASCT recipients compared to HIV+ patients. Whereas in HIV positive patients <i>effector memory</i> CD8+ T cells were the predominant memory phenotype, in ASCT recipients significantly higher levels of CD45RA+CCR7− <i>effector</i> CD8+ cells were evidenced. Each central bar represents the median value and each box corresponds to the 25^th through 75^th percentile (interquartile) range.