<i>NPY</i>^−/− mice are resistant to <i>S.T.</i>-induced colitis.

<p>(A) Representative sections of hematoxylin eosin (H/E) stained sections of colon from WT and <i>NPY </i>^−/− mice given water/<i>S.T.</i>. Arrows represent neutrophil infiltration and crypt damage. Magnification 10X and 40X. (B) Morphology of cecum (C) Percent cecum shrinkage in WT mice and <i>NPY</i>^−/− mice. Disease severity was assessed as described in the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0003304#s2" target="_blank">Materials and Methods</a> section in terms of (D) Histological score and (E) Myeloperoxidase activity. Each bar represents mean±S.E; n = 4, Significant difference from all other groups represented as *** p<0.001.