MicroRNAs are stable during serum handling.

<p>A) microRNA stability in serum samples was monitored by extracting RNA from serum samples kept for 1, 2 or 4 h at room temperature before freezing. The levels of 20 different microRNAs (blue circles), as well as of the 4 synthetic RNA ‘spike-ins’ (in the lower left part of the graph), were found to be similar across the 4 h time period. B) microRNA stability in serum samples was monitored by extracting RNA from serum samples before and after freezing. The levels of 20 different microRNAs (blue circles), as well as of the 4 synthetic RNA ‘spike-ins’ (in the lower left part of the graph), were found to be similar following re-freezing and re-thawing of the sample.