Analysis of <i>HYAL1</i> and <i>HYAL2</i> stably transformed KRC/Y clones.
- Fuli Wang (53208)
- Elvira V. Grigorieva (53209)
- Jingfeng Li (53210)
- Vera N. Senchenko (53211)
- Tatiana V. Pavlova (53212)
- Ekaterina A. Anedchenko (53213)
- Anna V. Kudryavtseva (53214)
- Alexander Tsimanis (53215)
- Debora Angeloni (53216)
- Michael I. Lerman (53217)
- Vladimir I. Kashuba (53218)
- George Klein (24180)
- Eugene R. Zabarovsky (53219)
Publication date
February 2013
DOIAbstract
<p>Northern analysis (A) of tetracycline regulated clones. (+), tetracycline (Tet) or doxycycline is present, gene is OFF. (−), tetracycline or doxycycline is absent, gene is ON. Growth inhibition of KRC/Y cells with <i>HYAL1</i> (B) and <i>HYAL2</i> (C) transgenes <i>in vitro</i>. Tumour growth inhibition of KRC/Y cells by <i>HYAL1</i> and <i>HYAL2 in vivo</i> in SCID mice (D). Mice were drinking water with tetracycline (+Tet, gene is OFF) or without (−Tet, gene is ON) but for simplicity curves are shown only for mice when genes were ON (no tetracycline).</p
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