Current Preclinical Testing Strategy for Candidate HIV-1 Vaccines

<p>A variety of approaches are used to evaluate the immunogenicity of a specific candidate HIV-1 vaccine, X. These approaches may or may not include testing immunogenicity of the HIV-1 vaccine itself in non-primates (e.g., rodents, rabbits, guinea pigs, etc.) or NHPs. In addition, the immunogenicity of an SIV or SHIV analogue of the HIV-1 vaccine may be tested in NHPs; this is done before NHP efficacy trials, which require challenge of NHPs with SIV or SHIV. Currently, neither immunogenicity nor challenge studies in NHPs are required preclinical assessments for candidate HIV-1 vaccines.