Some proteins corresponding to oxidized mRNA species are decreased.

<p>(A & B) immunofluorescent staining of lumbar spinal cord sections prepared from indicated mice (n = 3) showed that downregulation of protein levels in SOD1^G93A mice was found in cytochrome c oxidase VIb (<i>Cox VIb</i>) and NADH-ubiquinol oxidoreductase subunit 39 kDa (<i>NADH oxi</i>), whose mRNAs were highly oxidized but not EAAT3 protein, whose mRNA was not oxidized. Statistic analysis of immunoreactivity within motor neurons (n = 20) is shown. *<i>P</i><0.0001 (C) Immunoblot analysis showed that MBP, whose mRNA was oxidized, was decreased. Densitometry analysis (standardized by actin intensity) of immunoblot is shown (n = 3). #<i>P</i><0.01.