Growth and pathogenicity of H5N1 viruses

a<p>All data are the mean±SD from three independent experiments.</p>b<p>90–100% mortality in groups of 10 mice after intranasal inoculation with virus dose of 10³ EID₅₀ was considered as high pathogenicity; no mortality and disease signs after infection with similar virus dose was considered as low pathogenicity.</p>c<p>Severe systemic disease with mortality developed after intranasal infection with virus dose of 10⁶ EID₅₀ was considered as high pathogenicity; severe respiratory disease without mortality was considerate as moderate pathogenicity, and mild or asymptomatic respiratory infection without mortality as low pathogenicity.</p>d<p>Intravenous pathogenicity tests <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000102#ppat.1000102-World4" target="_blank">[46]</a> with all viruses killing 100% of inoculated chickens indicative of HPAI viruses.