Tumor growth in CsA-treated 129Sv mice and LOU/c rats after injection of ES cells or <i>in vitro</i> differentiated cells.

<p>(A) 1×10⁶ ES cells or <i>in vitro</i> differentiated cells were injected subcutaneously at day 0 into syngeneic 129Sv mice (for the numbers of animals see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0002622#pone-0002622-t002" target="_blank">Table 2</a>) which were treated daily with CsA (10 mg/kg body weight). The tumor size was recorded every second day until day 100 using linear calipers. The growth of tumors in individual mice is shown. Tumor growth in female hosts is indicated by red lines and male hosts by blue lines. (B) 1×10⁶ cells differentiated <i>in vitro</i> for 14 days were injected subcutaneously into LOU/c rats (n = 18) which were treated daily with CsA (10 mg/kg body weight). The tumor size was recorded every second day until day 100 using linear calipers. The growth of tumors in individual rats is shown. Tumor growth in female hosts is indicated by red and in male hosts by blue lines. One tumor in a female rat was not progressive and remained very small until the end of the experiment. In two male rats a tumor regression occurred.