Mitochondrial Morphology Abnormality in Purkinje Cell Dendrites of <i>Bcl-w^−/−</i>, <i>Grid2^−/−,</i> and <i>Bcl-w^−/−Grid2^{ho−4J/(−/−)}</i> Mice.

<p>(A) Electronmicrograph to show the morphology of mitochondria in dendritic track in wild type, <i>Bcl-w^−/−</i>, <i>Grid2^−/−,</i> and <i>Bcl-w^−/−Grid2^{ho−4J/(−/−)}</i> mice. Black arrows indicate dendritic spines, orange arrowhead the broken end of mitochondria, indicating mitochondria transiting out of section plate, and the blue arrows the constriction sites on mitochondria. (B) Histograph showing the length of mitochondria in Purkinje cell dendrites. Each lane represents one mouse. Square indicates wild type mice, solid triangle the <i>Bcl-w^−/−</i> mice, solid dot the <i>Grid2^−/−</i>mice, and diamond the <i>Bcl-w^−/−Grid2^{ho−4J(−/−)}</i> mice. A student t-test was performed on mitochondrial length among all listed mice. Three wild type mice are significantly different from all other mice in mitochondria length, p<0.0001. The mitochondrial lengths in two <i>Bcl-w^−/−Grid2^{ho−4J(−/−)}</i> mice are significantly different from that in single knockout mice, p<0.05. “n” indicates the number of mitochondria collected. (C) Semi-thin sections illustrating the presence of mitochondria in dendritic tracks in wild type, <i>Bcl-w^−/−</i>, <i>Grid2^−/−,</i> and <i>Bcl-w^−/−Grid2^{ho−4J(−/−)}</i> mice. The orange arrows point at mitochondria in Purkinje cell dendrites.