DDC and CCl₄ Cooperate with MYC to Induce Accelerated Liver Tumorigenesis.

<p>Shown are Kaplan-Meier survival curves for 6–8 w adult mice that overexpressed MYC and were simultaneously treated with: nothing (filled black square), DDC (filled blue circle), or CCl₄ (filled blue diamond). Adult mice treated with hepatotoxins in the absence of MYC overexpression (MYC OFF) are displayed with the corresponding open shape: nothing (empty black square), with DDC (empty blue circle), or CCl₄ (empty blue diamond). Also shown are survival curves of neonatal mice in which MYC was either overexpressed (filled red triangle), or remained inactive (empty red triangle) starting at birth. Cohorts consisted of 5–10 mice. MYC transgene expression was activated by removal of doxycycline from the mouse drinking water on the day of hepatotoxin treatment initiation. Mice were sacrificed when moribund with tumor burden.