Gene expression of CD44, LFA-1, MAC-1, VCAM-1, MCP-1, cathepsin B, eNOS, ICAM-1, and COX-2 in younger mice.

<p>Gene expression of CD44, LFA-1, MAC-1, VCAM-1, MCP-1, cathepsin B, eNOS, ICAM-1, and COX-2 in individual aortic arches expressed as % change relative to wild-type (<i>n</i> = 8 for all groups) from 10- (A) week old mice. Data from 6- (B) week old mice are from pooled aortas, due to the small sample size. Both sets of mice were on chow diet and normalized to cyclophilin D mRNA levels. ApoE^−/− mice had higher CD44, LFA-1, VCAM-1, cathepsin B, ICAM-1 and COX-2 gene expression than wild type mice (Bonferroni test, *p<0.05, **p<0.01, ***p<0.0001). Low-level apoE in transgenic mice suppressed the gene expression of LFA-1, VCAM-1, cathepsin B and ICAM-1 compared to apoE^−/− mice (Bonferroni test, †p<0.05, ‡p<0.0001).