Characteristics of disease progression in G93A mice.

<p>A) body weight, B) extension reflex, and C) rotorod test of G93A mice administered with three different cell doses, Media-injected, CsA-injected and control hTgn mice. At 16 wks and 20 wks of age, mice receiving 25×10⁶ cells better maintained their body weight, extended hindlimbs, and stayed longer on rotorod than other cell transplant or control groups. The four pointed stars in A, B, and C indicates significant difference: <i>in body weight</i>–16 wks of age: 25×10⁶ cells vs. 50×10⁶ cells (p<0.05); 20 wks of age: 25×10⁶ cells vs. CsA (p<0.05); <i>in extension reflex</i>–25×10⁶ cells vs. Media or 50×10⁶ cells (p<0.05); 20 wks of age-25×10⁶ cells vs. CsA or 10×10⁶ cells (p<0. 01); <i>in rotorod</i>–14 wks of age: 25×10⁶ cells vs. Media (p<0.05); in 20 wks of age-25×10⁶ cells vs. CsA (p<0.05) or 10×10⁶ cells (p< 0.01).