a<p>Survival, LD<sub>50</sub>, and mean time-to-death (MTD) were determined 21 days after infection for the lowest Schu S4 and Schu S4 Δ<i>purMCD</i>∶pTZ752 doses (10 CFU) given, and the highest Schu S4 Δ<i>purMCD</i> dose (10<sup>6</sup> CFU).</p>b<p>LD<sub>50</sub> values were calculated as described by Reed and Muench.</p
<p>BALB/c mice (n = 5/group) were immunized with 10<sup>3</sup> (squares), 10<sup>5</sup> (circles),...
<p>Six- to eight-week-old mice were inoculated i.m. or i.v. with 10<sup>6</sup> ffu of SB or DOG4. (...
<p>(A-D) Mice (n = 10–12 per group) were treated with T4 (500 ng) or vehicle (control) for three day...
<p>Groups of mice were infected i.n. (A, B, and C) or i.d. (D, E, and F) with wild-type Schu S4 (50 ...
<p>Mice (n = 5) were vaccinated i.d. (A) or i.n. (B) with 10-fold serial dilutions of Schu S4 Δ<i>pu...
<p>BALB/c mice (n = 4/group) were immunized ID with ∼10<sup>5</sup> CFU of FSC200 <i>ΔclpB</i> (circ...
<p>Four C57BL/6J mice in each group (seven- to twelve-week-old females; SLC, Inc. Shizuoka, Japan) w...
<p>(A) Balb/c mice (n = 10/group) were infected intradermally with the indicated number of <i>F. tul...
<p>(A) BALB/c mice (N = 5) were anesthetized and infected with various <i>F. tularensis</i> Schu S4 ...
<p>The durations of survival of mice infected with rVN-PB1(U) (A) and rVN-PB1(C) (B) with increasing...
a<p>Mice were immunized with either LVS or ΔFTL_0883 at the indicated dose and then challenged with ...
<p>In A) BALB/c mice were challenged intradermally with 1000 CFU of SCHU S4 (square), Δ<i>FTT0609</i...
<p>(A) CIs for the Δ<i>lgt</i> strain versus the wild-type strain in mouse models of septicaemia at ...
<p>Assessment of wtBUNV and rBUN4KR virulence in mice. Strain 129 mice were infected i.c. with 1000 ...
<p>(A) Kaplan-Meier survival curves of 6 week old mice inoculated with 7.3 log<sub>10</sub> pfu (■; ...
<p>BALB/c mice (n = 5/group) were immunized with 10<sup>3</sup> (squares), 10<sup>5</sup> (circles),...
<p>Six- to eight-week-old mice were inoculated i.m. or i.v. with 10<sup>6</sup> ffu of SB or DOG4. (...
<p>(A-D) Mice (n = 10–12 per group) were treated with T4 (500 ng) or vehicle (control) for three day...
<p>Groups of mice were infected i.n. (A, B, and C) or i.d. (D, E, and F) with wild-type Schu S4 (50 ...
<p>Mice (n = 5) were vaccinated i.d. (A) or i.n. (B) with 10-fold serial dilutions of Schu S4 Δ<i>pu...
<p>BALB/c mice (n = 4/group) were immunized ID with ∼10<sup>5</sup> CFU of FSC200 <i>ΔclpB</i> (circ...
<p>Four C57BL/6J mice in each group (seven- to twelve-week-old females; SLC, Inc. Shizuoka, Japan) w...
<p>(A) Balb/c mice (n = 10/group) were infected intradermally with the indicated number of <i>F. tul...
<p>(A) BALB/c mice (N = 5) were anesthetized and infected with various <i>F. tularensis</i> Schu S4 ...
<p>The durations of survival of mice infected with rVN-PB1(U) (A) and rVN-PB1(C) (B) with increasing...
a<p>Mice were immunized with either LVS or ΔFTL_0883 at the indicated dose and then challenged with ...
<p>In A) BALB/c mice were challenged intradermally with 1000 CFU of SCHU S4 (square), Δ<i>FTT0609</i...
<p>(A) CIs for the Δ<i>lgt</i> strain versus the wild-type strain in mouse models of septicaemia at ...
<p>Assessment of wtBUNV and rBUN4KR virulence in mice. Strain 129 mice were infected i.c. with 1000 ...
<p>(A) Kaplan-Meier survival curves of 6 week old mice inoculated with 7.3 log<sub>10</sub> pfu (■; ...
<p>BALB/c mice (n = 5/group) were immunized with 10<sup>3</sup> (squares), 10<sup>5</sup> (circles),...
<p>Six- to eight-week-old mice were inoculated i.m. or i.v. with 10<sup>6</sup> ffu of SB or DOG4. (...
<p>(A-D) Mice (n = 10–12 per group) were treated with T4 (500 ng) or vehicle (control) for three day...