Many lipophilic compounds are absorbed to some degree via the lymphatics, however, the mechanisms and factors controlling this absorption process are unclear. In order to provide some information on this area we have studied the effect of lipid vehicle on the lymphatic transport of isotretinoin following oral dosing to the rat. Oils containing higher percentages of the linoleate triglyceride ester appeared to promote both enhanced lymph flow and chylomicron concentration. Long chain triglyceride oils proved to be the most effective vehicles for increasing lymphatic transport - especially cottonseed oil and peanut oil. The solubility of the drug in the oil was also shown to be a key factor in lymphatic transpor
Liver Physiol. 2): GMLG353, 1980. The effect of chronic feed-ing (3-4 wk) of the hydrophobic surfact...
lymphatic apolipoprotein A-IV and B output and synthesis. Am. J. Physiol. 271 (Gastrointest. Liver P...
Abstract To elucidate the effect of simultaneously fed carbohydrate or protein on lipid absorption, ...
The retinoids are highly lipophilic molecules and are known to be transported in the intestinal lymp...
The effect of intraduodenal administration of fats was studied in the rat to define the mechanisms r...
The nonionic detergent, Pluronic L-81 (L-81) has been shown to block the transport of intestinal muc...
Oil and emulsion vehicles have been shown to alter the oral absorption of many drugs. This may be du...
[3H]Arachidonic (20:4) and [14C]linoleic acid (18:2) were fed to thoracic duct-cannulated rats in te...
terol, labeled with tracer doses of cholesterol 14C or cholesterol-'H and of near physiological...
Lipid-based formulations play a significant role in oral delivery of lipophilic drugs. Previous stud...
The triglyceride (TG) mimetic prodrug (1,3-dipalmitoyl-2-mycophenoloyl glycerol, 2-MPA-TG) biochemic...
From oils associated with the toxic syndrome have been isolated 3-phenylamino-1,2-aminophenol (PAP) ...
The sequential meal pattern has recently received more attention because it reflects a phycological ...
The intestinal lymphatic system transports fluid, immune cells, dietary lipids, and highly lipophili...
The lymphatic system plays a number of roles in key physiological and pathological events, including...
Liver Physiol. 2): GMLG353, 1980. The effect of chronic feed-ing (3-4 wk) of the hydrophobic surfact...
lymphatic apolipoprotein A-IV and B output and synthesis. Am. J. Physiol. 271 (Gastrointest. Liver P...
Abstract To elucidate the effect of simultaneously fed carbohydrate or protein on lipid absorption, ...
The retinoids are highly lipophilic molecules and are known to be transported in the intestinal lymp...
The effect of intraduodenal administration of fats was studied in the rat to define the mechanisms r...
The nonionic detergent, Pluronic L-81 (L-81) has been shown to block the transport of intestinal muc...
Oil and emulsion vehicles have been shown to alter the oral absorption of many drugs. This may be du...
[3H]Arachidonic (20:4) and [14C]linoleic acid (18:2) were fed to thoracic duct-cannulated rats in te...
terol, labeled with tracer doses of cholesterol 14C or cholesterol-'H and of near physiological...
Lipid-based formulations play a significant role in oral delivery of lipophilic drugs. Previous stud...
The triglyceride (TG) mimetic prodrug (1,3-dipalmitoyl-2-mycophenoloyl glycerol, 2-MPA-TG) biochemic...
From oils associated with the toxic syndrome have been isolated 3-phenylamino-1,2-aminophenol (PAP) ...
The sequential meal pattern has recently received more attention because it reflects a phycological ...
The intestinal lymphatic system transports fluid, immune cells, dietary lipids, and highly lipophili...
The lymphatic system plays a number of roles in key physiological and pathological events, including...
Liver Physiol. 2): GMLG353, 1980. The effect of chronic feed-ing (3-4 wk) of the hydrophobic surfact...
lymphatic apolipoprotein A-IV and B output and synthesis. Am. J. Physiol. 271 (Gastrointest. Liver P...
Abstract To elucidate the effect of simultaneously fed carbohydrate or protein on lipid absorption, ...