<p>The graph shows the number of self-infusion on the last 5 days of acquisition (day 6–10) and the transition to a 0.5 mg/kg/infusion dose (day 11–14). At the 0.5 mg/kg dose, DBA mice show a number of self-infusions that is comparable to that of the C57 mice at the 1 mg/kg/infusion dose. Symbols represent mean±SEM. C57 (squares) <i>n</i> = 8, DBA (triangles) <i>n</i> = 5.</p
RATIONALE: Few effective treatments exist for cocaine use disorders due to gaps in knowledge about i...
<p>Cocaine-induced locomotor activity in DAT/5-HT1B KO mice is expressed as absolute difference s fr...
<p>Male C57BL/6 mice were subjected to an intermittent chronic treatment (one day on/one day off for...
<p>Graphs show the number of self-infusions obtained in (a) C57 mice in acquisition at 1 mg/kg/infus...
<p><b>A)</b> The number of cocaine infusions earned by βarr1 KO mice (KO: n = 21) during the first 5...
<p>This data set represents the number of cocaine infusions each subject earned for the last two day...
RATIONALE: Cocaine addiction is a major public health problem with a substantial genetic basis for w...
<p>(A) Drug-naïve <i>Dbh +/−</i> (n = 9) and <i>Dbh −/−</i> mice (n = 8) were placed in automated lo...
Intravenous drug self-administration is the most valid animal model of human addiction because it al...
Rationale: Cocaine addiction is a major public health problem with a substantial genetic basis for w...
<p>(A) Context dependent sensitization. Cumulative 30 min locomotor response to cocaine (15 mg/kg, i...
<p>This plot shows the number of infusions earned across ten days of self-administration of cocaine ...
<p>This data set represents the number of infusions (1a) and the frequency of nose-pokes in the acti...
RATIONALE: Drug addiction is a disease with a genetic component that may be involved in different st...
Tested whether Lewis and Fischer rat strains differ in acquisition or maintenance of intravenous coc...
RATIONALE: Few effective treatments exist for cocaine use disorders due to gaps in knowledge about i...
<p>Cocaine-induced locomotor activity in DAT/5-HT1B KO mice is expressed as absolute difference s fr...
<p>Male C57BL/6 mice were subjected to an intermittent chronic treatment (one day on/one day off for...
<p>Graphs show the number of self-infusions obtained in (a) C57 mice in acquisition at 1 mg/kg/infus...
<p><b>A)</b> The number of cocaine infusions earned by βarr1 KO mice (KO: n = 21) during the first 5...
<p>This data set represents the number of cocaine infusions each subject earned for the last two day...
RATIONALE: Cocaine addiction is a major public health problem with a substantial genetic basis for w...
<p>(A) Drug-naïve <i>Dbh +/−</i> (n = 9) and <i>Dbh −/−</i> mice (n = 8) were placed in automated lo...
Intravenous drug self-administration is the most valid animal model of human addiction because it al...
Rationale: Cocaine addiction is a major public health problem with a substantial genetic basis for w...
<p>(A) Context dependent sensitization. Cumulative 30 min locomotor response to cocaine (15 mg/kg, i...
<p>This plot shows the number of infusions earned across ten days of self-administration of cocaine ...
<p>This data set represents the number of infusions (1a) and the frequency of nose-pokes in the acti...
RATIONALE: Drug addiction is a disease with a genetic component that may be involved in different st...
Tested whether Lewis and Fischer rat strains differ in acquisition or maintenance of intravenous coc...
RATIONALE: Few effective treatments exist for cocaine use disorders due to gaps in knowledge about i...
<p>Cocaine-induced locomotor activity in DAT/5-HT1B KO mice is expressed as absolute difference s fr...
<p>Male C57BL/6 mice were subjected to an intermittent chronic treatment (one day on/one day off for...