Model analysis of the effects of fibroblast density and proliferation rate on keratinocyte expansion.

<p>Within the user-defined flat square surface (500 µm×500 µm), the initial keratinocyte stem cell number in all the simulations was defined as 10, while the initial fibroblast number varied from 0 to 50. The fibroblast proliferation rates simulated were: 0% (white column), 10% (light grey column), 30% (dark grey column), 50% (black column), 70% (dotted column) and 90% (lined column). Simulation results shown are mean±SD (n = 10).