The proposed model for siderophore mediated iron transport in <i>M.tb</i> involving the IrtA and the IrtB-Rv2895c two component system.

<p>The active export of siderophores mediated by the IrtA and its subsequent internalization, upon sequestering of host iron, by the IrtB-Rv2895c in an energy dependent manner, appears to constitute the cycle of iron transport in mycobacteria. SIM represents the siderophore interacting motif; SBD, siderophore binding domain of IrtA; WA is the walker A motif; WB is walker B motif and SM is ABC transporter signature motif.