<p>Intracellular expression of Ki-67 (A) and surface expression of CD69 (B) were monitored after 7 days of cell culture in medium or with the stimuli as indicated. Bars represent means and the lines standard errors of the mean (SEM) of 15 separate experiments using PBMC of healthy controls. Black boxes = CD4+ T cells and gray boxes = CD8+ T cells. * = nominally significantly different (p<0.05 by Wilcoxon Sign Rank test when compared to results obtained in medium alone.</p
<p><i>In vitro</i> activation of HEK cells containing a murine TLR2/1 or TLR2/6 reporter construct i...
<p>Cluster plot of results of three independent replicates, plotted as fluorescence intensity for ea...
<p>a) Images of CD69 stained T-cells in M− and M+ conditions. Green- CD69, Greenish black- antigen-c...
<p>Intracellular Ki-67 expression (3A, 3C) and cell surface CD69 (3B, 3D) were analyzed after 7 days...
<p>661W cells were challenged with the indicated TLR ligands for 8h and the secretion of inflammator...
<p>PBMCs from 8 HDs were treated with LRAs for 6 h, washed, then cultured for up to three days and e...
(A) CD8 T cell related marker expression of transferred P14 CD8 T cells 30 days post-infection. Left...
<p>(A) PP cells (5.8×10<sup>5</sup> cells) from WT (white), TLR2<sup>−/−</sup> (black), TLR4<sup>−/−...
<p>(A) Human PBMCs (2x10<sup>5</sup> cells/well) were stimulated with the TLR9-ligands CpG-ODN 2006 ...
<p>(A, B) <i>Tlr9</i><sup><i>-/-</i></sup> BMDCs expressing HA-tagged TLR9 WT, Y870F, or Y870A were ...
<p>BMDM were incubated overnight with DMSO or 200 µM MTA in the absence or presence of the following...
<p>Splenic γδ T cells of MyD88<sup>−/−</sup> (<i>A</i>–<i>D</i>) or TLR7<sup>−/−</sup> mice (<i>E</i...
<p>(A) Freshly purified PBLs stained for CD4, CD8, CD3, HLA-DR, CD16, CD56. Depletion controls for P...
<p>Whole splenocytes were stimulated directly <i>ex vivo</i> with the indicated ligands (the numbers...
<p>Bars indicate the median, significance was defined as p≤0.05 (*). A. Representative histograms of...
<p><i>In vitro</i> activation of HEK cells containing a murine TLR2/1 or TLR2/6 reporter construct i...
<p>Cluster plot of results of three independent replicates, plotted as fluorescence intensity for ea...
<p>a) Images of CD69 stained T-cells in M− and M+ conditions. Green- CD69, Greenish black- antigen-c...
<p>Intracellular Ki-67 expression (3A, 3C) and cell surface CD69 (3B, 3D) were analyzed after 7 days...
<p>661W cells were challenged with the indicated TLR ligands for 8h and the secretion of inflammator...
<p>PBMCs from 8 HDs were treated with LRAs for 6 h, washed, then cultured for up to three days and e...
(A) CD8 T cell related marker expression of transferred P14 CD8 T cells 30 days post-infection. Left...
<p>(A) PP cells (5.8×10<sup>5</sup> cells) from WT (white), TLR2<sup>−/−</sup> (black), TLR4<sup>−/−...
<p>(A) Human PBMCs (2x10<sup>5</sup> cells/well) were stimulated with the TLR9-ligands CpG-ODN 2006 ...
<p>(A, B) <i>Tlr9</i><sup><i>-/-</i></sup> BMDCs expressing HA-tagged TLR9 WT, Y870F, or Y870A were ...
<p>BMDM were incubated overnight with DMSO or 200 µM MTA in the absence or presence of the following...
<p>Splenic γδ T cells of MyD88<sup>−/−</sup> (<i>A</i>–<i>D</i>) or TLR7<sup>−/−</sup> mice (<i>E</i...
<p>(A) Freshly purified PBLs stained for CD4, CD8, CD3, HLA-DR, CD16, CD56. Depletion controls for P...
<p>Whole splenocytes were stimulated directly <i>ex vivo</i> with the indicated ligands (the numbers...
<p>Bars indicate the median, significance was defined as p≤0.05 (*). A. Representative histograms of...
<p><i>In vitro</i> activation of HEK cells containing a murine TLR2/1 or TLR2/6 reporter construct i...
<p>Cluster plot of results of three independent replicates, plotted as fluorescence intensity for ea...
<p>a) Images of CD69 stained T-cells in M− and M+ conditions. Green- CD69, Greenish black- antigen-c...