<p>The tissues with self-renewing TAC stages evolve more quickly than the tissues with strict serial differentiation, where, with the exception of the stem cells, both daughter cells of a mitosis differentiate into the next differentiation stage. TACs, dashed lines; serial symmetric differentiation, solid lines.</p
<p>Case 1 simulations, in which stem cell proliferation is increased ( = 0.07/day), are plotted with...
<p>At each generation, CSCs can divide symmetrically, giving rise to two CSCs with probability or t...
<p>(<i>a</i>) Sphere formation rates were determined over several generations (gen.) by seeding sing...
<p>The series includes stem cells (stage 0, in white), TACs (in gray), and finally, terminally diffe...
<p>Each data point represents 500 trials with standard error bars. Cells that cannot apoptose (morta...
<p>Each curve is labeled with the number of differentiation stages in the model (1 = self-duplicatio...
<p>The fastest pathway of both cases is DGR, but the probabilities of stem-cell division are markedl...
<p>In this formulation, each stem can undergo two types of division, either symmetric (with probabil...
<p>Stem cell number and Niche Succession Period for different values of symmetric division probabili...
During mammalian development and homeostasis, cells often transition from a multilineage primed stat...
<p>The time to first cancer stem cell is faster for increased symmetric self-renewal when all mutati...
<p>(A) T2EC were induced to differentiate for 24 and 48 h and subsequently seeded back in self-renew...
<p>A: The Pedigree Concept. Key characteristics for this model of self-renewal are a preprogrammed d...
Here we study how the structure and growth of a cellular population vary with the distribution of ma...
<p>Lines represent averages for each of the three realisations in each scenario. (Left). Low vascula...
<p>Case 1 simulations, in which stem cell proliferation is increased ( = 0.07/day), are plotted with...
<p>At each generation, CSCs can divide symmetrically, giving rise to two CSCs with probability or t...
<p>(<i>a</i>) Sphere formation rates were determined over several generations (gen.) by seeding sing...
<p>The series includes stem cells (stage 0, in white), TACs (in gray), and finally, terminally diffe...
<p>Each data point represents 500 trials with standard error bars. Cells that cannot apoptose (morta...
<p>Each curve is labeled with the number of differentiation stages in the model (1 = self-duplicatio...
<p>The fastest pathway of both cases is DGR, but the probabilities of stem-cell division are markedl...
<p>In this formulation, each stem can undergo two types of division, either symmetric (with probabil...
<p>Stem cell number and Niche Succession Period for different values of symmetric division probabili...
During mammalian development and homeostasis, cells often transition from a multilineage primed stat...
<p>The time to first cancer stem cell is faster for increased symmetric self-renewal when all mutati...
<p>(A) T2EC were induced to differentiate for 24 and 48 h and subsequently seeded back in self-renew...
<p>A: The Pedigree Concept. Key characteristics for this model of self-renewal are a preprogrammed d...
Here we study how the structure and growth of a cellular population vary with the distribution of ma...
<p>Lines represent averages for each of the three realisations in each scenario. (Left). Low vascula...
<p>Case 1 simulations, in which stem cell proliferation is increased ( = 0.07/day), are plotted with...
<p>At each generation, CSCs can divide symmetrically, giving rise to two CSCs with probability or t...
<p>(<i>a</i>) Sphere formation rates were determined over several generations (gen.) by seeding sing...