Weighted Averages of Protein Length (10) and Expression Level (11)

<p>To determine which protein and expression levels are most relevant for the amount of abnormal proteins in a cell, we calculated weighted averages of protein length (solid line) and expression level (dashed line). As weights, we used the amount of expected abnormal proteins, . For small phenotypic mutation rates, highly expressed proteins are most relevant for the amount of abnormal proteins in a cell. This begins to change at <i>u</i> = 5 × 10⁻⁴, when lowly expressed, large proteins begin to dominate<i>x̄</i>. Inaccurate protein synthesis makes it practically impossible to synthesize these larger proteins error-free.