Model Predictions of the Overall Cell and Viral Dynamics

<p>The time evolution of the number of uninfected cells, <i>T</i>, the total number of infected cells, <i>T^*</i>, and the total viral load, <i>V</i>, following the onset of infection obtained by the solution of <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0030205#pcbi-0030205-e001" target="_blank">Equations 1</a>–<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0030205#pcbi-0030205-ea006" target="_blank">6</a> with the following parameter values: the initial target cell number, <i>T</i>₀ = 10⁶; the initial viral load, 2<i>V</i>₀ = 10⁸; the birth and death rates of uninfected cells, <i>λ</i> = 0.624 d⁻¹ and <i>μ</i> = 0.018 d⁻¹; the death rate of infected cells, <i>δ</i> = 1.44 d⁻¹; the viral burst size, <i>N</i> = 1,000; the clearance rate of free virions, <i>c</i> = 0.35 d⁻¹; the infection rate constant of uninfected cells, <i>k</i>₀ = 2 × 10⁻¹⁰ d⁻¹; the CD4 down-modulation timescale, <i>t</i>_d = 0.28 d; the recombination rate, <i>ρ</i> = 8.3 × 10⁻⁴ crossovers per position; and the separation between the mutations on genomes 1 and 2, <i>l</i> = 408 base pairs.