Schematic Representation of Two Genomic Regions That Involve CNVs Associated with SLE [65,66]

<div><p>(A) The region of Chromosome 1 containing the <i>FCGR3</i> gene cluster is highly variable and contains segmental duplications with a high sequence identity. Several CNVs have been reported that span this region. The genomic organization of the cluster is highly complex and not well solved in the current assembly of the genome sequence. The Affymetrix 500K and Illumina HumanHap 550 arrays do not cover this region well (red dotted lines).</p><p>(B) The region of Chromosome 6p21, containing the <i>C4A</i> and <i>C4B</i> genes, is embedded in a region of complex genomic organization [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0030190#pgen-0030190-b067" target="_blank">67</a>,<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0030190#pgen-0030190-b069" target="_blank">69</a>,<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0030190#pgen-0030190-b070" target="_blank">70</a>]. The region has been shown to contain segmental duplications and CNVs. The Affymetrix 500K and Illumina HumanHap 550 genotyping platforms do not cover this region, either (red dotted lines).</p>