Frequency of recognition of HIV-1 B consensus 2001 peptides as a function of their similarity to human proteins.

<p>410 peptides spanning the HIV-1 B consensus 2001 proteome were tested by ELISpot using PBMC from a cohort of 314 HIV-1 infected individuals. The vertical axis corresponds to the percentage of individuals who recognized a given peptide. The horizontal axis corresponds to the number of matches to the human proteome for each peptide. Matches were derived by dissecting the 410 peptides into overlapping 6-mers offset by one residue, and then scored against the RefSeq protein sequence database. Matches were normalized to account for the length of the starting peptide (ranging from 15–20 AA in length).