Effects of the eEF1 complex mutants on mis-reading of near- and non-cognate codons.

<p>Misreading of the non-cognate UCU and near-cognate AGC codons by mutant forms of eEF1A (Panel A), or by isogenic strains with <i>tef3Δ, tef4Δ</i>, or <i>tef3Δ tef4Δ</i> double null mutants or <i>tef5Δ</i> strains expressing the K120R S121Δ I122Δ allele compared to isogenic wild-type strain (Panel B). Panel C. Misreading of all seven missense codons by cells lacking both forms of eEF1Bγ (<i>tef3Δ tef4Δ</i>). Effects of the indicated mutants are depicted as fold of isogenic wild-type cells. ** indicates <i>p</i> values of <0.01; * indicates <i>p</i> values of <0.05.