<p>IL-2 activated human NK cells can kill multiple targets. IL-2 activated primary human NK cells were co-incubated with <sup>51</sup>Cr labeled 221 target cells at an E∶T ratio of 0.8∶1 to 0.05∶1 for 4 and 16 hours. (A) 51 Cr release assay was used to calculate % specific lysis for 4 and 16 hours duration. (B) % specific lysis was used to calculate killing frequency by dividing the number of target cells killed by number of effector cells used for each E∶T ratio. (C) Killing frequency of IL-2 activated NK cells using four independent donors for 4 and 16 hours duration.</p
<p>(<b>A</b>) Intracellular Ca<sup>2+</sup>-mobilization induced by activating NK cell receptors. Th...
<p><b>A</b>, Purified polyclonal IL-2–activated NK cells, derived from Pt1 (triangle pointing up) or...
NK cells are innate lymphocytes critical for immune surveillance, particularly in eradication of met...
<p>IL-2 restores the killing ability of inactivated NK cells. IL-2 activated NK cells were incubated...
<p>(A) NK cells were stimulated for four days with IL-2 (200 U/ml) and used as effector cells agains...
<p>Increasing the killing frequency of fresh NK cells by cytokines and Rituximab. (A) Freshly isolat...
<p>Rituximab increases killing frequency of IL-2 activated NK cells. 221 target cells were treated w...
BACKGROUND: Natural killer cells are an important component of the innate immune system. Anti-cancer...
<p>(A) Dynamic measure of MelC cell index (CI) alone (black dots) and in presence of immunoselected ...
<p>Highly purified NK cells were left untreated or treated with anti-CD16 mAb (3 µg/ml), IL-2 (1000 ...
<p>(A–B) Pre-incubation (16h) of NK- and OPM-1 MM cells were performed as indicated on the <i>x</i>-...
<p>The indicated NK cells were assessed for cytotoxic activity against target cancer cells using a c...
<p>Serial killing of tumor cells by NK cells is mediated by Perforin and Granzyme B. (A) IL-2 activa...
<p>A—Analysis of NK-cell cytotoxicity following NK-cell activation with TLR9-stimulated pDCs in cont...
<p>A. Incubation of NK cells with RS4;11 cells induced degranulation, which was significantly higher...
<p>(<b>A</b>) Intracellular Ca<sup>2+</sup>-mobilization induced by activating NK cell receptors. Th...
<p><b>A</b>, Purified polyclonal IL-2–activated NK cells, derived from Pt1 (triangle pointing up) or...
NK cells are innate lymphocytes critical for immune surveillance, particularly in eradication of met...
<p>IL-2 restores the killing ability of inactivated NK cells. IL-2 activated NK cells were incubated...
<p>(A) NK cells were stimulated for four days with IL-2 (200 U/ml) and used as effector cells agains...
<p>Increasing the killing frequency of fresh NK cells by cytokines and Rituximab. (A) Freshly isolat...
<p>Rituximab increases killing frequency of IL-2 activated NK cells. 221 target cells were treated w...
BACKGROUND: Natural killer cells are an important component of the innate immune system. Anti-cancer...
<p>(A) Dynamic measure of MelC cell index (CI) alone (black dots) and in presence of immunoselected ...
<p>Highly purified NK cells were left untreated or treated with anti-CD16 mAb (3 µg/ml), IL-2 (1000 ...
<p>(A–B) Pre-incubation (16h) of NK- and OPM-1 MM cells were performed as indicated on the <i>x</i>-...
<p>The indicated NK cells were assessed for cytotoxic activity against target cancer cells using a c...
<p>Serial killing of tumor cells by NK cells is mediated by Perforin and Granzyme B. (A) IL-2 activa...
<p>A—Analysis of NK-cell cytotoxicity following NK-cell activation with TLR9-stimulated pDCs in cont...
<p>A. Incubation of NK cells with RS4;11 cells induced degranulation, which was significantly higher...
<p>(<b>A</b>) Intracellular Ca<sup>2+</sup>-mobilization induced by activating NK cell receptors. Th...
<p><b>A</b>, Purified polyclonal IL-2–activated NK cells, derived from Pt1 (triangle pointing up) or...
NK cells are innate lymphocytes critical for immune surveillance, particularly in eradication of met...