<div><p>(A–D) Survival curves are for (A) SJL mice, (B) C57Bl/6 mice, (C) RIII mice, and (D) VM mice.</p><p>(E) Western blot analysis of proteinase K-treated brain homogenates from SJL, RIII, C57Bl/6, and VM mice challenged with BSE.</p><p>(F) Western blot analysis of brain homogenates from SJL, RIII, C57Bl/6, and VM mice challenged with BASE and a BSE-infected SJL mouse used as positive control (last lane). The first two lanes correspond to the same SJL mouse prior to and after proteinase K digestion, while all other samples were digested with proteinase K. The blots were probed with the anti-PrP antibody 6H4.</p></div
<p>Survival periods of PrP<sup>sc</sup> positive TgOvPrP4 mice are shown according the level of PrP<...
<p>Except for one undigested lane (−), brain samples were digested with PK (+ in panel A). All inocu...
Ctrl; saline. dpi; days post-inoculation. *Numbers indicate the first (1) and second (2) passages. I...
<p>BSE-affected mice were killed at 0, 40, 80, 120, and 150 dpi (terminal stage). (A) PrP detection ...
<div><p>(A) Primary or secondary (lane 6) transmission to tgBov mice. BSE-type inocula include cattl...
<div><p>(A) Survival curves and (B) lesion profiles for mice infected with BSE and BASE. (B) Vacuola...
<p>Mice were challenged by oral (lane 5–8) or the intra-cerebral route (lanes 1–4). A) Western blot ...
<p>Mice were challenged by oral (lane 5–8) or the intra-cerebral route (lanes 1–4). A) Western blot ...
<p>PrP<sup>Sc</sup> was precipitated by mAbs 6A12 and 8D5 from brain homogenate [0.05% (w/v)] from B...
<p>Mice were inoculated with classical CJD and GSS A117V brain. Immunoblots were analysed by enhance...
(A) Western blot analysis of the brain, spleen, and distal region of the ileum of representative mic...
<p>(<b>A</b>) Brain homogenates from terminally ill wt and PrP(TetraH>G) line 34 mice were either le...
Brain homogenates at 1% from challenged mice were digested with 85 μg/mL (for original isolates) or ...
10% brain homogenates from challenged mice were digested with 170 μg/mL of proteinase K and analyzed...
<p>Immunoblots of brain PrP<sup>res</sup> detected with SHA 31 and 12B2 mAbs. Similar quantities of ...
<p>Survival periods of PrP<sup>sc</sup> positive TgOvPrP4 mice are shown according the level of PrP<...
<p>Except for one undigested lane (−), brain samples were digested with PK (+ in panel A). All inocu...
Ctrl; saline. dpi; days post-inoculation. *Numbers indicate the first (1) and second (2) passages. I...
<p>BSE-affected mice were killed at 0, 40, 80, 120, and 150 dpi (terminal stage). (A) PrP detection ...
<div><p>(A) Primary or secondary (lane 6) transmission to tgBov mice. BSE-type inocula include cattl...
<div><p>(A) Survival curves and (B) lesion profiles for mice infected with BSE and BASE. (B) Vacuola...
<p>Mice were challenged by oral (lane 5–8) or the intra-cerebral route (lanes 1–4). A) Western blot ...
<p>Mice were challenged by oral (lane 5–8) or the intra-cerebral route (lanes 1–4). A) Western blot ...
<p>PrP<sup>Sc</sup> was precipitated by mAbs 6A12 and 8D5 from brain homogenate [0.05% (w/v)] from B...
<p>Mice were inoculated with classical CJD and GSS A117V brain. Immunoblots were analysed by enhance...
(A) Western blot analysis of the brain, spleen, and distal region of the ileum of representative mic...
<p>(<b>A</b>) Brain homogenates from terminally ill wt and PrP(TetraH>G) line 34 mice were either le...
Brain homogenates at 1% from challenged mice were digested with 85 μg/mL (for original isolates) or ...
10% brain homogenates from challenged mice were digested with 170 μg/mL of proteinase K and analyzed...
<p>Immunoblots of brain PrP<sup>res</sup> detected with SHA 31 and 12B2 mAbs. Similar quantities of ...
<p>Survival periods of PrP<sup>sc</sup> positive TgOvPrP4 mice are shown according the level of PrP<...
<p>Except for one undigested lane (−), brain samples were digested with PK (+ in panel A). All inocu...
Ctrl; saline. dpi; days post-inoculation. *Numbers indicate the first (1) and second (2) passages. I...