Heterogeneous Distribution of Mutational Robustness

<p>The histogram shows the distribution of the fraction <i>R_μ</i> of neighbors of a network that differ at one regulatory interaction but attain the same equilibrium gene expression state <b>S</b>_∞. The data is obtained from a sample of 10⁴ networks (<i>N</i> = 20; <i>M</i> ≈ 0.5 <i>N²; d</i> = 0.7) sampled from the metagraph in a Monte Carlo simulation as outlined in Methods.