Kaplan-Meier survival estimation for stage IV patients only by mutational status.

<p>Curves showing the overall survival starting with the time point of tumor biopsy in 82 metastatic melanoma patients who were in stage IV disease at that time. Survival probabilities were compared by the mutational status of B-RAF in tumor tissue biopsies (n = 70) (A) and biopsy-derived tumor cell lines (n = 80) (D), as well as N-RAS in tumor tissue biopsies (n = 70) (B) and biopsy-derived tumor cell lines (n = 80) (E). (C) and (F) differentiate patients harbouring B-RAF mutations (n = 43, tissues; n = 45, cell lines), patients harbouring N-RAS mutations (n = 12, tissues; n = 15; cell lines), and patients without mutations in both genes (n = 15, tissues; n = 20, cell lines). Statistical differences between groups were calculated using the log-rank test. Vertical bars indicate censored observations.