<p>Tumor tissue biopsies and biopsy-derived cell lines from 109 metastatic melanoma patients were analysed for B-RAF and N-RAS mutations. For details see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000236#pone-0000236-g001" target="_blank"><i>Figure 1</i></a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000236#pone-0000236-t002" target="_blank"><i>Table 2</i></a>. *This cell line additionally carries the N-RAS Q61K mutation.</p
Next generation sequencing (NGS) has been used to characterize the overall genomic landscape of mela...
In comparison to other human cancer types, malignant melanoma exhibits the greatest amount of hetero...
In comparison to other human cancer types, malignant melanoma exhibits the greatest amount of hetero...
In melanoma, the RAS/RAF/MEK/ERK signalling pathway is an area of great interest, because it regulat...
Mutations in the ras gene are key events in the process of carcinogenesis; in particular, point muta...
Mutations in the ras genes are key events in the process of carcinogenesis; in particular, point mut...
<p>DNA was extracted from 97 tissue biopsies and 105 biopsy-derived cell lines from 109 metastatic m...
Ras gene mutations have been implicated in the pathogenesis of a variety of human tumors. Mutated ra...
In this study we address whether there is an association between ras mutations and disease progressi...
Mutations in the ras genes are key events in the process of carcinogenesis; in particular, point mut...
Journal URL: http://www.spandidos-publications.com/or/Melanomas are malignant tumours with high meta...
Testing for NRAS is now integral part in the assessment of metastatic melanoma patients because the...
N-RAS mutation at codon 12, 13 or 61 is associated with transformation; yet, in melanoma, such alter...
Oral mucosal melanoma (OMM) is a fatal sarcoma of unknown etiology. Histological morphology and gene...
<p>Migration patterns under non-denaturing conditions of single stranded fragments of exon 15 of the...
Next generation sequencing (NGS) has been used to characterize the overall genomic landscape of mela...
In comparison to other human cancer types, malignant melanoma exhibits the greatest amount of hetero...
In comparison to other human cancer types, malignant melanoma exhibits the greatest amount of hetero...
In melanoma, the RAS/RAF/MEK/ERK signalling pathway is an area of great interest, because it regulat...
Mutations in the ras gene are key events in the process of carcinogenesis; in particular, point muta...
Mutations in the ras genes are key events in the process of carcinogenesis; in particular, point mut...
<p>DNA was extracted from 97 tissue biopsies and 105 biopsy-derived cell lines from 109 metastatic m...
Ras gene mutations have been implicated in the pathogenesis of a variety of human tumors. Mutated ra...
In this study we address whether there is an association between ras mutations and disease progressi...
Mutations in the ras genes are key events in the process of carcinogenesis; in particular, point mut...
Journal URL: http://www.spandidos-publications.com/or/Melanomas are malignant tumours with high meta...
Testing for NRAS is now integral part in the assessment of metastatic melanoma patients because the...
N-RAS mutation at codon 12, 13 or 61 is associated with transformation; yet, in melanoma, such alter...
Oral mucosal melanoma (OMM) is a fatal sarcoma of unknown etiology. Histological morphology and gene...
<p>Migration patterns under non-denaturing conditions of single stranded fragments of exon 15 of the...
Next generation sequencing (NGS) has been used to characterize the overall genomic landscape of mela...
In comparison to other human cancer types, malignant melanoma exhibits the greatest amount of hetero...
In comparison to other human cancer types, malignant melanoma exhibits the greatest amount of hetero...