UVB Transcriptional Profile in the Basal Epidermis of Normal (<i>+/+</i>) P2.5 Mice

<div><p>(A) Heatmap of UVB-responsive genes. The ordered columns represent replicate samples of sham- (black) and UVB- (blue) irradiated mice, and the rows represent log₂ ratios for 1,434 UVB-responsive genes. Data are displayed as a pseudocolor heatmap where red, green, and black represent induction, repression, and no change, respectively, relative to the median. Gray represents missing data. The ratio fold-change is indicated by a scale bar. Genes are ranked by their average fold change (Δ) value. The average fold Δ value was obtained by dividing the average expression level of each gene in the experimental (UVB-irradiated) group by that in the control (sham-irradiated) group. Average expression levels for the experimental and control groups are represented as log₂ ratios ±SEM. The top ten ranked genes for the repressed and induced responses are listed along with their corresponding average fold change (Δ) and Student's <i>t</i>-test <i>p</i>-values. In some cases, official mouse gene symbols are used, instead of the lengthier gene names.</p><p>(B) Distribution of fold-change differences for UVB-responsive genes. Fold-change differences were obtained by comparing sham- and UVB-irradiated mice. Data were binned into one of five fold-change classes for each of the repressed and induced responses. The total number of genes sorted into each bin is shown above each class.</p>