Mouse plasma cell tumor tissue culture (PCT-TC) signature and survival analysis of human cancer patients

<p>27 RNA samples from 17 solid mouse plasma cell tumors and 10 tissue cultured mouse PCT-TC cell lines (including Baf3, a pre-B cell line) were used for the generation of PCT-TC signature. <b>A.</b> Mouse plasma cell tumor tissue culture signature. 1162 genes showing significant differences in expression between solid PCTs and tissue-cultured PCTs were selected by SAM analysis at the 99-percentile confidence level with a 0.001 FDR. <b>B–D.</b> Kaplan-Meier survival analysis of human cancer patients groups generated by unsupervised cluster analysis with mouse PCT-TC signature. <b>B.</b> Survival analysis of human mantle cell lymphoma patients group <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000145#pone.0000145-Rosenwald1" target="_blank">[12]</a> generated by unsupervised cluster analysis with 694 orthologs of the mouse PCT-TC signature genes. <b>C.</b> Survival analysis of human liver cancer patients <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000145#pone.0000145-Lee2" target="_blank">[13]</a> generated by unsupervised cluster analysis with 971 orthologs of the mouse PCT-TC signature genes. <b>D.</b> Survival analysis of human breast cancer patients <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000145#pone.0000145-vandeVijver1" target="_blank">[2]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000145#pone.0000145-vantVeer1" target="_blank">[3]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000145#pone.0000145-Chang1" target="_blank">[15]</a> generated by unsupervised cluster analysis with 470 orthologs of the mouse PCT-TC signature genes.