Relationship of CD4+ T cell Proliferation against HCV Antigens to CD8+ IFN-γ Responses

CD127 Expression, Exhaustion Status and Antigen Specific Proliferation Predict Sustained Virologic Response to IFN in HCV/HIV Co-Infected Individuals

Hassen Kared (175532)
Sahar Saeed (595108)
Marina B. Klein (138788)
Naglaa H. Shoukry (53608)

July 2014

<div>Hepatitis C virus (HCV) infection is a major cause of morbidity and mortality in the HIV co-...

Hepatitis C virus nonstructural protein specific T cells are associated with virological responses to combination therapy in chronic HCV patients.

Zhang, Y
Liu, Y
Zhao, Y
Shi, L
Ma, L
Yan, H
Wu, H
Wei, L
Dong, T
Chen, X

January 2012

BACKGROUND: Virus-specific T-cell responses play a major role in antiviral immune response. However,...

Diminished frequency of hepatitis C virus specific interferon gamma secreting CD4+ T cells in human immunodeficiency virus/hepatitis C virus coinfected patients.

Harcourt, G
Gomperts, E
Donfield, S
Klenerman, P

October 2006

BACKGROUND: Human immunodeficiency virus/hepatitis C virus (HIV/HCV) coinfection is a common and com...

Sustained virologic response to IFN-α therapy correlates with higher HIV- and HCV-specific proliferation of CD4 and CD8 T cells at baseline.

Hassen Kared (175532)
Sahar Saeed (595108)
Marina B. Klein (138788)
Naglaa H. Shoukry (53608)

July 2014

Proliferation of HIV- and HCV-specific CD4 and CD8 T cells in response to HIV P24 (A, B) and HCV ...

The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1

Kim, A.Y.
Lauer, G.M.
Ouchi, K.
Addp, M.M.
Lucas, M.
Schulze zur Wiesch, J.
Timm, J.
Boczanowski, M.
Duncan, J.E.
Wurcel, A.G.
Casson, D.
Chung, R.T.
Draenert, R.
Klenerman, P.
Walker, B.D.

January 2004

CD8+ T-cell responses are an essential antiviral host defense in persistent viral infections, and th...

The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1.

Kim, A
Lauer, G
Ouchi, K
Addo, M
Lucas, M
Schulze Zur Wiesch, J
Timm, J
Boczanowski, M
Duncan, J
Wurcel, A
Casson, D
Chung, RT
Draenert, R
Klenerman, P
Walker, B

January 2005

CD8(+) T-cell responses are an essential antiviral host defense in persistent viral infections, and ...

HCV specific T cell responses are important in the control of HCV viral load and are higher in HCV mono infected patients.

Yong-Hong Zhang (102903)
Yan Zhao (58882)
Ushani S. Rajapaksa (3147615)
Tessa M. Lawrence (427203)
Yan-Chun Peng (3147609)
Jinghua Liu (189882)
Keyi Xu (3147606)
Ke Hu (84619)
Ling Qin (68169)
Ning Liu (168279)
Huanqin Sun (3147612)
Hui-Ping Yan (179455)
Emmanouela Repapi (220397)
Sarah Rowland-Jones (74678)
Robert Thimme (76852)
Jane A. McKeating (343022)
Tao Dong (15551)

July 2016

A) HCV core and NS protein specific T cell responses were compared between a sub group of ...

Differences in HCV-specific T cell responses between chronic HCV infection and HIV/HCV co-infection

Dutoit, V.
Ciuffreda, D.
Comte, D.
Gonvers, J. J.
Pantaleo, G.

December 2005

Hepatitis C virus (HCV)-specific CD4+ and CD8+ T cell responses were investigated using a panel of 7...

Polychromatic FACS analysis of viral-specific T cells in HCV/HIV co-infection.

Bahareh Vali (153048)
Feng Yun Yue (153052)
R. Brad Jones (272883)
Prameet M. Sheth (345820)
Rupert Kaul (34935)
Michael R. Betts (111925)
David Wong (189814)
Colin Kovacs (93789)
Mona Loutfy (376364)
Andrew Common (376365)
Roberta Halpenny (376366)
Mario A. Ostrowski (153083)

February 2013

Shown are representative FACS data of the HIV and HCV specific multi-parameter CD8+ T-...

Polyfunctional HCV-specific T-cell responses are associated with effective control of HCV replication

Ciuffreda, Donatella
Comte, Denis
Cavassini, Matthias
Giostra, Emiliano
Buehler, Leo Hans
Perruchoud, Monika
Heim, Markus H.
Battegay, Manuel
Genne, Daniel
Mulhaupt, Beat
Malinverni, Raffaele
Oneta, Carl
Bernasconi, Enos
Monnat, Martine
Cerny, Andreas
Chuard, Christian Robert
Borovicka, Jan
Mentha, Gilles
Pascual, Manuel
Gonvers, Jean-Jacques
Pantaleo, Giuseppe
Dutoit, Valerie

January 2008

HCV infection has a severe course of disease in HIV/HCV co-infection and in liver transplant recipie...

Antigen-specific cytokine production by intra-hepatic T-cells in HCV mono-infection and HCV/HIV co-infection.

Bahareh Vali (153048)
Feng Yun Yue (153052)
R. Brad Jones (272883)
Prameet M. Sheth (345820)
Rupert Kaul (34935)
Michael R. Betts (111925)
David Wong (189814)
Colin Kovacs (93789)
Mona Loutfy (376364)
Andrew Common (376365)
Roberta Halpenny (376366)
Mario A. Ostrowski (153083)

February 2013

Figure (a) represents the summary data of the percentage of intra-hepatic CD4+ T-cells...

Sustained virologic response to IFN-α therapy correlates with higher baseline and on treatment expression of CD127 while non-response correlates with increased CD8 T cell activation.

Hassen Kared (175532)
Sahar Saeed (595108)
Marina B. Klein (138788)
Naglaa H. Shoukry (53608)

July 2014

Resting and activated CD8 T cells were defined as CD127+CD38neg and HLA-DR<...

CD127 expression, exhaustion status and antigen specific proliferation predict sustained virologic response to IFN in HCV/HIV co-infected individuals.

Hassen Kared
Sahar Saeed
Marina B Klein
Naglaa H Shoukry

Hepatitis C virus (HCV) infection is a major cause of morbidity and mortality in the HIV co-infected...

Direct-acting antiviral therapy enhances total CD4+ and CD8+ T-cells responses, but does not alter T-cells activation among HCV mono-infected, and HCV/HIV-1 co-infected patients

Najafi Fard, Saeid
Schietroma, Ivan
Corano Scheri, Giuseppe
Giustini, Noemi
Serafino, Sara
Cavallari, Eugenio Nelson
Pinacchio, Claudia
DE GIROLAMO, Gabriella
Ceccarelli, Giancarlo
Scagnolari, Carolina
Vullo, Vincenzo
D'Ettorre, Gabriella

January 2017

AIM: Chronic immune activation and poor T-cell immune response are strongly associated with disease...

HCV-Specific T Cell Responses before and after HCV Recurrence in HIV+ Participants with Prior Spontaneous Control

Arthur Y Kim (22792)
Julian Schulze zur Wiesch (22793)
Thomas Kuntzen (22794)
Joerg Timm (22795)
Daniel E Kaufmann (22796)
Jared E Duncan (22797)
Andrea M Jones (22798)
Alysse G Wurcel (22799)
Benjamin T Davis (22800)
Rajesh T Gandhi (22801)
Gregory K Robbins (22802)
Todd M Allen (22803)
Raymond T Chung (22804)
Georg M Lauer (22805)
Bruce D Walker (22806)

February 2013

<div>(A) LP responses before and after HCV recurrence. Responses to c33c (NS3) and NS5 declined a...

CD127 Expression, Exhaustion Status and Antigen Specific Proliferation Predict Sustained Virologic Response to IFN in HCV/HIV Co-Infected Individuals

Hassen Kared (175532)
Sahar Saeed (595108)
Marina B. Klein (138788)
Naglaa H. Shoukry (53608)

July 2014

<div>Hepatitis C virus (HCV) infection is a major cause of morbidity and mortality in the HIV co-...

Hepatitis C virus nonstructural protein specific T cells are associated with virological responses to combination therapy in chronic HCV patients.

Zhang, Y
Liu, Y
Zhao, Y
Shi, L
Ma, L
Yan, H
Wu, H
Wei, L
Dong, T
Chen, X

January 2012

BACKGROUND: Virus-specific T-cell responses play a major role in antiviral immune response. However,...

Diminished frequency of hepatitis C virus specific interferon gamma secreting CD4+ T cells in human immunodeficiency virus/hepatitis C virus coinfected patients.

Harcourt, G
Gomperts, E
Donfield, S
Klenerman, P

October 2006

BACKGROUND: Human immunodeficiency virus/hepatitis C virus (HIV/HCV) coinfection is a common and com...

Sustained virologic response to IFN-α therapy correlates with higher HIV- and HCV-specific proliferation of CD4 and CD8 T cells at baseline.

Hassen Kared (175532)
Sahar Saeed (595108)
Marina B. Klein (138788)
Naglaa H. Shoukry (53608)

July 2014

Proliferation of HIV- and HCV-specific CD4 and CD8 T cells in response to HIV P24 (A, B) and HCV ...

The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1

Kim, A.Y.
Lauer, G.M.
Ouchi, K.
Addp, M.M.
Lucas, M.
Schulze zur Wiesch, J.
Timm, J.
Boczanowski, M.
Duncan, J.E.
Wurcel, A.G.
Casson, D.
Chung, R.T.
Draenert, R.
Klenerman, P.
Walker, B.D.

January 2004

CD8+ T-cell responses are an essential antiviral host defense in persistent viral infections, and th...

The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1.

Kim, A
Lauer, G
Ouchi, K
Addo, M
Lucas, M
Schulze Zur Wiesch, J
Timm, J
Boczanowski, M
Duncan, J
Wurcel, A
Casson, D
Chung, RT
Draenert, R
Klenerman, P
Walker, B

January 2005

CD8(+) T-cell responses are an essential antiviral host defense in persistent viral infections, and ...

HCV specific T cell responses are important in the control of HCV viral load and are higher in HCV mono infected patients.

Yong-Hong Zhang (102903)
Yan Zhao (58882)
Ushani S. Rajapaksa (3147615)
Tessa M. Lawrence (427203)
Yan-Chun Peng (3147609)
Jinghua Liu (189882)
Keyi Xu (3147606)
Ke Hu (84619)
Ling Qin (68169)
Ning Liu (168279)
Huanqin Sun (3147612)
Hui-Ping Yan (179455)
Emmanouela Repapi (220397)
Sarah Rowland-Jones (74678)
Robert Thimme (76852)
Jane A. McKeating (343022)
Tao Dong (15551)

July 2016

A) HCV core and NS protein specific T cell responses were compared between a sub group of ...

Differences in HCV-specific T cell responses between chronic HCV infection and HIV/HCV co-infection

Dutoit, V.
Ciuffreda, D.
Comte, D.
Gonvers, J. J.
Pantaleo, G.

December 2005

Hepatitis C virus (HCV)-specific CD4+ and CD8+ T cell responses were investigated using a panel of 7...

Polychromatic FACS analysis of viral-specific T cells in HCV/HIV co-infection.

Bahareh Vali (153048)
Feng Yun Yue (153052)
R. Brad Jones (272883)
Prameet M. Sheth (345820)
Rupert Kaul (34935)
Michael R. Betts (111925)
David Wong (189814)
Colin Kovacs (93789)
Mona Loutfy (376364)
Andrew Common (376365)
Roberta Halpenny (376366)
Mario A. Ostrowski (153083)

February 2013

Shown are representative FACS data of the HIV and HCV specific multi-parameter CD8+ T-...

Polyfunctional HCV-specific T-cell responses are associated with effective control of HCV replication

Ciuffreda, Donatella
Comte, Denis
Cavassini, Matthias
Giostra, Emiliano
Buehler, Leo Hans
Perruchoud, Monika
Heim, Markus H.
Battegay, Manuel
Genne, Daniel
Mulhaupt, Beat
Malinverni, Raffaele
Oneta, Carl
Bernasconi, Enos
Monnat, Martine
Cerny, Andreas
Chuard, Christian Robert
Borovicka, Jan
Mentha, Gilles
Pascual, Manuel
Gonvers, Jean-Jacques
Pantaleo, Giuseppe
Dutoit, Valerie

January 2008

HCV infection has a severe course of disease in HIV/HCV co-infection and in liver transplant recipie...

Antigen-specific cytokine production by intra-hepatic T-cells in HCV mono-infection and HCV/HIV co-infection.

Bahareh Vali (153048)
Feng Yun Yue (153052)
R. Brad Jones (272883)
Prameet M. Sheth (345820)
Rupert Kaul (34935)
Michael R. Betts (111925)
David Wong (189814)
Colin Kovacs (93789)
Mona Loutfy (376364)
Andrew Common (376365)
Roberta Halpenny (376366)
Mario A. Ostrowski (153083)

February 2013

Figure (a) represents the summary data of the percentage of intra-hepatic CD4+ T-cells...

Sustained virologic response to IFN-α therapy correlates with higher baseline and on treatment expression of CD127 while non-response correlates with increased CD8 T cell activation.

Hassen Kared (175532)
Sahar Saeed (595108)
Marina B. Klein (138788)
Naglaa H. Shoukry (53608)

July 2014

Resting and activated CD8 T cells were defined as CD127+CD38neg and HLA-DR<...

CD127 expression, exhaustion status and antigen specific proliferation predict sustained virologic response to IFN in HCV/HIV co-infected individuals.

Hassen Kared
Sahar Saeed
Marina B Klein
Naglaa H Shoukry

Hepatitis C virus (HCV) infection is a major cause of morbidity and mortality in the HIV co-infected...

Direct-acting antiviral therapy enhances total CD4+ and CD8+ T-cells responses, but does not alter T-cells activation among HCV mono-infected, and HCV/HIV-1 co-infected patients

Najafi Fard, Saeid
Schietroma, Ivan
Corano Scheri, Giuseppe
Giustini, Noemi
Serafino, Sara
Cavallari, Eugenio Nelson
Pinacchio, Claudia
DE GIROLAMO, Gabriella
Ceccarelli, Giancarlo
Scagnolari, Carolina
Vullo, Vincenzo
D'Ettorre, Gabriella

January 2017

AIM: Chronic immune activation and poor T-cell immune response are strongly associated with disease...

HCV-Specific T Cell Responses before and after HCV Recurrence in HIV+ Participants with Prior Spontaneous Control

Arthur Y Kim (22792)
Julian Schulze zur Wiesch (22793)
Thomas Kuntzen (22794)
Joerg Timm (22795)
Daniel E Kaufmann (22796)
Jared E Duncan (22797)
Andrea M Jones (22798)
Alysse G Wurcel (22799)
Benjamin T Davis (22800)
Rajesh T Gandhi (22801)
Gregory K Robbins (22802)
Todd M Allen (22803)
Raymond T Chung (22804)
Georg M Lauer (22805)
Bruce D Walker (22806)

February 2013

<div>(A) LP responses before and after HCV recurrence. Responses to c33c (NS3) and NS5 declined a...

CD127 Expression, Exhaustion Status and Antigen Specific Proliferation Predict Sustained Virologic Response to IFN in HCV/HIV Co-Infected Individuals

Hassen Kared (175532)
Sahar Saeed (595108)
Marina B. Klein (138788)
Naglaa H. Shoukry (53608)

July 2014

<div>Hepatitis C virus (HCV) infection is a major cause of morbidity and mortality in the HIV co-...

Hepatitis C virus nonstructural protein specific T cells are associated with virological responses to combination therapy in chronic HCV patients.

Zhang, Y
Liu, Y
Zhao, Y
Shi, L
Ma, L
Yan, H
Wu, H
Wei, L
Dong, T
Chen, X

January 2012

BACKGROUND: Virus-specific T-cell responses play a major role in antiviral immune response. However,...

Diminished frequency of hepatitis C virus specific interferon gamma secreting CD4+ T cells in human immunodeficiency virus/hepatitis C virus coinfected patients.

Harcourt, G
Gomperts, E
Donfield, S
Klenerman, P

October 2006

BACKGROUND: Human immunodeficiency virus/hepatitis C virus (HIV/HCV) coinfection is a common and com...

Relationship of CD4<sup>+</sup> T cell Proliferation against HCV Antigens to CD8<sup>+</sup> IFN-γ Responses

Abstract

Extracted data

Relationship of CD4<sup>+</sup> T cell Proliferation against HCV Antigens to CD8<sup>+</sup> IFN-γ Responses

Abstract

Extracted data

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