HCV-Specific T Cell Responses before and after HCV Recurrence in HIV+ Participants with Prior Spontaneous Control

<div><p>(A) LP responses before and after HCV recurrence. Responses to c33c (NS3) and NS5 declined after the establishment of viremia. By contrast, stimulation indices to HIV-1 p24 antigen and phytohemagglutinin (positive control) increased.</p> <p>(B–E) The degree of viremia is shown in shaded gray for four participants. IFN-γ measurements are in spot-forming cell (SFC)/10⁶ PBMCs. The cumulative HCV CD8⁺ T cell response is represented by the solid red lines. In three participants who demonstrated decline in HCV-specific CD8⁺ T cell responses, Epstein–Barr virus (EBV) response to the lytic A2 epitope (GLCTLVAML) is shown by the blue dashed lines.</p>