Effect of VEGF Capillary Distribution and HSPG on VEGF Gradients

<div><p>(A) Uniform capillary distribution results in a decrease in the average VEGF gradients in the tissue.</p><p>(B,C) VEGF gradients at steady state are invariant (in percentage terms) to changes in the extracellular matrix composition. Increased density or affinity of VEGF binding sites results in increased bound VEGF content (and thus increased absolute values of the gradient), but no change in the relative gradient.</p>