<p>Increasing VEGFR2 density (A) and increasing VEGFR1 density (B) increase the gradients of VEGF concentration in tissue. Surfaces represent concentration of total VEGF (pM, free plus HSPG-bound) in the ECM across the cross section of tissue. Histograms of VEGF gradients and the percentage of tissue involved. Gradient defined as in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0020127#pcbi-0020127-g002" target="_blank">Figure 2</a>.</p
<p><b>(A)</b> Levels of free VEGF, PlGF, and sR1 in tissue interstitial fluid, normalized to baselin...
<p><b>A-C.</b> Total VEGFR2 phosphorylated on at least one of Y951, Y1175, and Y1214 (pR2, A) and si...
<p>Remark that although the VEGFR-2 receptor is down-regulated, the VEGF concentration is high enoug...
<div><p>(A) Uniform capillary distribution results in a decrease in the average VEGF gradients in th...
<div><p>(A) Increased binding affinity (increased on-rate) has a similar outcome to increases in the...
<p>The distribution of VEGF binding on vessels for one, two, and three 40-fold overexpressing fibers...
Vascular endothelial growth factor-A (VEGF) is the master determinant for the activation of the angi...
Vascular endothelial growth factor (VEGF) is a potent cytokine that binds to specific receptors on t...
<p><b>A</b>–<b>F</b>, Receptor phosphorylation dynamics in response to VEGF concentrations: (A,D) 50...
Vascular endothelial growth factor-A (VEGF) is the master determinant for the activation of the angi...
<p>All panels show area under the curve (AUC), a measure of total VEGFR2 activation, for the first 6...
<p>Free VEGF in the normal tissue, blood, and diseased tissue compartments in response to anti-VEGF ...
<p>Evolution of the average VEGFR-2 concentration (day 0 corresponds to the time of fracture). The t...
<p>A. Visualization of fit trafficking parameters. Red dots indicate a representative coherent set o...
<p>Free VEGF at steady state in the healthy body model by updating VEGFR1 and VEGFR2 levels from the...
<p><b>(A)</b> Levels of free VEGF, PlGF, and sR1 in tissue interstitial fluid, normalized to baselin...
<p><b>A-C.</b> Total VEGFR2 phosphorylated on at least one of Y951, Y1175, and Y1214 (pR2, A) and si...
<p>Remark that although the VEGFR-2 receptor is down-regulated, the VEGF concentration is high enoug...
<div><p>(A) Uniform capillary distribution results in a decrease in the average VEGF gradients in th...
<div><p>(A) Increased binding affinity (increased on-rate) has a similar outcome to increases in the...
<p>The distribution of VEGF binding on vessels for one, two, and three 40-fold overexpressing fibers...
Vascular endothelial growth factor-A (VEGF) is the master determinant for the activation of the angi...
Vascular endothelial growth factor (VEGF) is a potent cytokine that binds to specific receptors on t...
<p><b>A</b>–<b>F</b>, Receptor phosphorylation dynamics in response to VEGF concentrations: (A,D) 50...
Vascular endothelial growth factor-A (VEGF) is the master determinant for the activation of the angi...
<p>All panels show area under the curve (AUC), a measure of total VEGFR2 activation, for the first 6...
<p>Free VEGF in the normal tissue, blood, and diseased tissue compartments in response to anti-VEGF ...
<p>Evolution of the average VEGFR-2 concentration (day 0 corresponds to the time of fracture). The t...
<p>A. Visualization of fit trafficking parameters. Red dots indicate a representative coherent set o...
<p>Free VEGF at steady state in the healthy body model by updating VEGFR1 and VEGFR2 levels from the...
<p><b>(A)</b> Levels of free VEGF, PlGF, and sR1 in tissue interstitial fluid, normalized to baselin...
<p><b>A-C.</b> Total VEGFR2 phosphorylated on at least one of Y951, Y1175, and Y1214 (pR2, A) and si...
<p>Remark that although the VEGFR-2 receptor is down-regulated, the VEGF concentration is high enoug...