<p>(A) LANA protein associates with the Cul5/Rbx1 module but not Cul2/Rbx1 module, and (B) Elongin BC complex increases interaction of LANA with the Cul5/Roc1 module. Saos-2 cells were transfected with expression vector encoding the indicated proteins in the figure. The lysates underwent IP using anti-myc antibodies. Crude extracts (left panels) and immune complexes (right panels) were separated by SDS-PAGE and IB with the indicated antibodies.</p
<p>(<b>A</b>) Co-immunoprecipitation of endogenous LANA and MRN proteins in BC3 cells. Cells were ly...
A, B, To investigate whether the phosphorylation of H2A and Cdc20 by Bub1 were inhibited in the pres...
Cellular protein degradation pathways can be utilized by viruses to establish an environment that fa...
<div><p>(A) The amino-terminal domain of LANA directly interacts with Elongin C but not Elongin B in...
<div><p>(A) The stabilities of WT LANA and its SOCS motif mutant. Five million Saos-2 cells were tra...
<div><p>(A) KSHV LANA contains a putative SOCS-box motif which includes a consensus of BC-box and Cu...
<p>(A) Schematic of the various SOCS-constructs that were used. (B) Hek293T cells were transfected w...
A, B, HEK293 were transfected with indicated plasmids. 48 hours later, cells were collected and lyse...
<p>(<b>A</b>) LANA interacts with poly-SUMO2 not poly-SUMO1 modified chain of KAP1. HEK293 cells wer...
<p><b>A.</b> HA tagged Histone H1, H2B, MeCP2, DEK, HMG-N1 and HMG-N2 were co-transfected with LANA-...
<div><p>(A) The amino-terminal domain of LANA binding <i>VHL</i> and carboxyl-terminal domain bindin...
The Elongin complex was originally identified as a positive regulator of RNA polymerase II. The Elon...
<p>Nuclear extract was harvested from BCBL-1 cells (A) or BC-3 cells (B) and LTC-TIVE (C). The nucle...
(A) LANA colocalized with NDRG1 and PCNA in the nucleus. Cells were fixed and probed with rat antibo...
<p>(A) Schematic strategy showing tandem affinity purification of SF-tagged LANA Complex. (B, C) Rec...
<p>(<b>A</b>) Co-immunoprecipitation of endogenous LANA and MRN proteins in BC3 cells. Cells were ly...
A, B, To investigate whether the phosphorylation of H2A and Cdc20 by Bub1 were inhibited in the pres...
Cellular protein degradation pathways can be utilized by viruses to establish an environment that fa...
<div><p>(A) The amino-terminal domain of LANA directly interacts with Elongin C but not Elongin B in...
<div><p>(A) The stabilities of WT LANA and its SOCS motif mutant. Five million Saos-2 cells were tra...
<div><p>(A) KSHV LANA contains a putative SOCS-box motif which includes a consensus of BC-box and Cu...
<p>(A) Schematic of the various SOCS-constructs that were used. (B) Hek293T cells were transfected w...
A, B, HEK293 were transfected with indicated plasmids. 48 hours later, cells were collected and lyse...
<p>(<b>A</b>) LANA interacts with poly-SUMO2 not poly-SUMO1 modified chain of KAP1. HEK293 cells wer...
<p><b>A.</b> HA tagged Histone H1, H2B, MeCP2, DEK, HMG-N1 and HMG-N2 were co-transfected with LANA-...
<div><p>(A) The amino-terminal domain of LANA binding <i>VHL</i> and carboxyl-terminal domain bindin...
The Elongin complex was originally identified as a positive regulator of RNA polymerase II. The Elon...
<p>Nuclear extract was harvested from BCBL-1 cells (A) or BC-3 cells (B) and LTC-TIVE (C). The nucle...
(A) LANA colocalized with NDRG1 and PCNA in the nucleus. Cells were fixed and probed with rat antibo...
<p>(A) Schematic strategy showing tandem affinity purification of SF-tagged LANA Complex. (B, C) Rec...
<p>(<b>A</b>) Co-immunoprecipitation of endogenous LANA and MRN proteins in BC3 cells. Cells were ly...
A, B, To investigate whether the phosphorylation of H2A and Cdc20 by Bub1 were inhibited in the pres...
Cellular protein degradation pathways can be utilized by viruses to establish an environment that fa...