Detection of CD8<sup>+</sup> T Lymphocytes Recognizing HLA-A2.1–Restricted ts Epitopes in Patients with Chronic Chagas Disease
- Diana L Martin (63907)
- D. Brent Weatherly (14141)
- Susana A Laucella (63908)
- Melissa A Cabinian (63909)
- Matthew T Crim (63910)
- Susan Sullivan (63911)
- Mark Heiges (13997)
- Sarah H Craven (63912)
- Charles S Rosenberg (63913)
- Matthew H Collins (63914)
- Alessandro Sette (19132)
- Miriam Postan (63915)
- Rick L Tarleton (48161)
Publication date
February 2013
DOIAbstract
<p>PBMCs were stained using MHC tetramers specific for the TSA2–38 or TSA2–44 epitopes. The percentage of CD8<sup>+</sup> T cells staining positive for TSA2–38 is shown for a representative chronic chagasic patient and an uninfected control. Cells shown are lymphocytes gated on CD4<sup>neg</sup>B220<sup>neg</sup>CD11b<sup>neg</sup> lymphocytes. Five out of eight IFNγ ELISPOT<sup>+</sup> subjects stained positive with tetramers.</p
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