Comparisons of the Data Obtained in the gTOW Experiment with Other Qualitative and Quantitative Datasets

<div><p>(A) The plasmid copy numbers in the gTOW experiment with essential genes and nonessential genes [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020111#pgen-0020111-b009" target="_blank">9</a>,<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020111#pgen-0020111-b041" target="_blank">41</a>].</p><p>(B) A scatter plot between protein abundance obtained by Ghaemmaghami et al. [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020111#pgen-0020111-b026" target="_blank">26</a>] and the plasmid copy number in the gTOW experiment.</p><p>(C) A scatter plot of growth inhibitions between the <i>GAL</i> experiment and gTOW experiment with the 30 <i>CDC</i> genes.</p><p>(D) A scatter plot between protein abundance determined by Cross et al. [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020111#pgen-0020111-b021" target="_blank">21</a>] and the plasmid copy number of B-type cyclins in the gTOW experiment. The protein abundance is the number of copies per log-phase yeast cell of the indicated cyclin protein C-terminally tagged with protein A expressed from the endogenous promoter and chromosomal location [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020111#pgen-0020111-b021" target="_blank">21</a>].</p><p>(E) A scatter plot between selectable disadvantage determined by Cross et al. [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020111#pgen-0020111-b021" target="_blank">21</a>] and the plasmid copy number of B-type cyclins in the gTOW experiment. The selective disadvantage parameter reflects differences in doubling time between wild-type and mutant cells. The data used in the graphs are listed in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020111#pgen-0020111-st001" target="_blank">Tables S1</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020111#pgen-0020111-st002" target="_blank">S2</a>, and <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020111#pgen-0020111-st003" target="_blank">S3</a>.</p>