Improving the discrimination of benign and malignant breast MRI lesions using the apparent diffusion coefficient

This paper presents an investigation of the apparent diffusion coefficient (ADC) for improving the discrimination of benign and malignant lesions in breast magnetic resonance imaging (MRI). In particular a method is presented for automatically selecting hyperintense tumour voxels in dynamic contrast enhanced (DCE) MRI data and evaluating their average ADC in the corresponding diffusion-weighted (DW) MRI data. The method was applied to ten breast MRI datasets obtained from routine clinical practice. The results demonstrate that the combination of the relative signal increase (DCE-MRI) with the apparent diffusion coefficient (DW-MRI) leads to better discrimination than with either feature alone. The results also suggest that it is important to acquire the DW-MRI data in a consistent fashion; i.e. either before or after the acquisition of the DCE-MRI data. © 2010 Crown Copyright