An Expression Cluster of Genes Enriched for Pnt AND Twi AND Tin

<div><p>(A) Clustering of the 159 FC genes and the 12 expression profiles of Estrada et al. [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0020053#pcbi-0020053-b021" target="_blank">21</a>], using self-organizing map clustering followed by hierarchical clustering. Note that all columns are median-centered. The red box indicates a gene cluster (C1) that contains <i>eve</i> and whose genes show similar expression profiles. Here, abbreviations are EGFR = <i>EGF receptor</i> gof; FGFR = <i>FGF receptor</i> gof; Arm+Ras = <i>armadillo</i> and <i>Ras</i> gof; Ras = <i>Ras</i> gof; Pnt = <i>pointed</i> gof; Arm = <i>armadillo</i> gof; Dl = <i>Delta</i> lof; Lmd = <i>Lameduck</i> lof; Wg = <i>wingless</i> lof; Spi = <i>spitz</i> lof; Tkv = <i>thickveins</i> gof; N = <i>Notch</i> gof.</p><p>(B) Detection rate curves for the OR combination of dTCF/Mad/Pnt/Twi/Tin using C1 as a foreground gene set.</p><p>(C–E) Area between C1 and non-C1 detection curves is shown when scanning with the TFs dTCF/Mad/Pnt/Twi/Tin either individually (C), with all AND and OR combinations involving four or five TFs (D), or all AND combinations involving three TFs (E). Dotted lines indicate threshold statistical significance values of <i>p</i> < 0.01 and <i>p</i> < 0.001, as computed by WMW.</p><p>(F) Detection rate curves for Pnt AND Twi AND Tin combinations using C1 as a foreground gene set.</p>