Survival Analyses of Human Lung AD Subclasses from Bhattacharjee et al. [ 10] Based on Lung Developmental Association

<div><p>(A) AD samples identified as forming two distinct subclasses C2 and C4 by Bhattacharjee et al. seen from the genomic PC1 and PC3 perspective of the 472-gene mouse lung development framework. Each sample point is color-coded by its survival time. Circles indicate members of class C4, diamonds indicate members of class C2, and “X”s correspond to all other AD samples.</p> <p>(B) Same as in (A), except that here only the stage I AD samples (such samples within C2, C4, and other) are highlighted. The mouse genomic PC1 halfway separation value between the C2 and C4 samples is noted.</p> <p>(C) K-M plot based on 64 stage I AD patients separated into two groups by the mouse PC1 halfway separation value from (B) ( <i>p =</i> 0.0169); the low-survival group has 13 patients and the high-survival group has 51 patients. </p>