SAA Is a Potent Proinflammatory Mediator

<p>Human coronary artery endothelial cells (HCAECs, A), adipose stromal vascular cells (SVCs, B) and mouse RAW264 monocytes (C) were treated with vehicle (PBS, white bar), low (0.47 μg ml⁻¹, hatched bar), or high (2.34 μg ml⁻¹, black bar) concentrations of recombinant human SAA for 8 h in serum-free medium. Cell-free supernatants were then assayed for cytokines. Data are expressed as mean ± SEM from <i>n</i> = 3–5 independent experiments. Statistical significance (* <i>p</i> < 0.05; ** <i>p</i> < 0.01; two sample <i>t</i>-test) was observed between the SAA-treated groups and vehicle.