Identifying High-Confidence TF–Target Interactions and TF Modules

<p>Different lines of evidence indicative of TF–target interactions are combined to yield an integrated probabilistic measure of interaction propensity. Using a positive and a negative validation set, the input evidences are independently converted into LLSs. Individual LLSs are integrated into one value per TF–target pair. TF modules are identified as subsets of TFs that regulate common genes.